GRK4 (G protein-coupled receptor kinase 4)

2006-10-01  

Identity

HGNC
GRK4
LOCATION
4p16.3
LOCUSID
2868
ALIAS
GPRK2L,GPRK4,GRK4a,IT11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2868
MIM: 137026
HGNC: 4543
Ensembl: ENSG00000125388

Variants:

dbSNP: 2868
ClinVar: 2868
TCGA: ENSG00000125388
COSMIC: GRK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125388ENST00000345167P32298
ENSG00000125388ENST00000398051P32298
ENSG00000125388ENST00000398052P32298
ENSG00000125388ENST00000503518D6REW5
ENSG00000125388ENST00000504933P32298

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166152848hypertensive nephrosclerosisDiseaseClinicalAnnotationassociatedPD
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD22949529
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD22949529
PA444682Kidney DiseasesDiseaseClinicalAnnotationassociatedPD
PA445086NephrosclerosisDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD22949529
PA450480metoprololChemicalClinicalAnnotationassociatedPD
PA451868verapamilChemicalClinicalAnnotationassociatedPD22949529

References

Pubmed IDYearTitleCitations
366696432023Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.3
366696432023Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.3
354872862022Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.5
354872862022Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.5
323495332021Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.12
331272682021Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.6
332800212021The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.15
338996252021Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.2
342977692021Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.2
323495332021Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.12
331272682021Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.6
332800212021The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.15
338996252021Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.2
342977692021Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.2
313490212019Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells.3

Citation

Dessen P

GRK4 (G protein-coupled receptor kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43301/grk4-(g-protein-coupled-receptor-kinase-4)