Identity
HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
GPRK2L,GPRK4,GRK4a,IT11
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2868
MIM: 137026
HGNC: 4543
Ensembl: ENSG00000125388
Variants:
dbSNP: 2868
ClinVar: 2868
TCGA: ENSG00000125388
COSMIC: GRK4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166152848 | hypertensive nephrosclerosis | Disease | ClinicalAnnotation | associated | PD | ||
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 22949529 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 22949529 | |
| PA444682 | Kidney Diseases | Disease | ClinicalAnnotation | associated | PD | ||
| PA445086 | Nephrosclerosis | Disease | ClinicalAnnotation | associated | PD | ||
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 22949529 | |
| PA450480 | metoprolol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451868 | verapamil | Chemical | ClinicalAnnotation | associated | PD | 22949529 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36669643 | 2023 | Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. | 3 |
| 36669643 | 2023 | Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. | 3 |
| 35487286 | 2022 | Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. | 5 |
| 35487286 | 2022 | Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. | 5 |
| 32349533 | 2021 | Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension. | 12 |
| 33127268 | 2021 | Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population. | 6 |
| 33280021 | 2021 | The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. | 15 |
| 33899625 | 2021 | Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. | 2 |
| 34297769 | 2021 | Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang. | 2 |
| 32349533 | 2021 | Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension. | 12 |
| 33127268 | 2021 | Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population. | 6 |
| 33280021 | 2021 | The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. | 15 |
| 33899625 | 2021 | Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. | 2 |
| 34297769 | 2021 | Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang. | 2 |
| 31349021 | 2019 | Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells. | 3 |
Citation
Dessen P
GRK4 (G protein-coupled receptor kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43301/grk4-(g-protein-coupled-receptor-kinase-4)
