HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1)
2006-10-01 AffiliationIdentity
HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
MDFPMR,p532,p619
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8925
MIM: 605109
HGNC: 4867
Ensembl: ENSG00000103657
Variants:
dbSNP: 8925
ClinVar: 8925
TCGA: ENSG00000103657
COSMIC: HERC1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37932766 | 2023 | CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis. | 6 |
| 37932766 | 2023 | CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis. | 6 |
| 34990797 | 2022 | The Herc1 gene in neurobiology. | 2 |
| 34990797 | 2022 | The Herc1 gene in neurobiology. | 2 |
| 34446601 | 2021 | Identification of a quality-control factor that monitors failures during proteasome assembly. | 12 |
| 34446601 | 2021 | Identification of a quality-control factor that monitors failures during proteasome assembly. | 12 |
| 31965002 | 2020 | The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling. | 12 |
| 32921582 | 2020 | A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism. | 4 |
| 31965002 | 2020 | The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling. | 12 |
| 32921582 | 2020 | A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism. | 4 |
| 27108999 | 2016 | A splice site mutation in HERC1 leads to syndromic intellectual disability with macrocephaly and facial dysmorphism: Further delineation of the phenotypic spectrum. | 17 |
| 27108999 | 2016 | A splice site mutation in HERC1 leads to syndromic intellectual disability with macrocephaly and facial dysmorphism: Further delineation of the phenotypic spectrum. | 17 |
| 25408501 | 2015 | Resistance to UV-induced apoptosis by β-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase. | 25 |
| 26138117 | 2015 | Biallelic HERC1 mutations in a syndromic form of overgrowth and intellectual disability. | 22 |
| 25408501 | 2015 | Resistance to UV-induced apoptosis by β-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase. | 25 |
Citation
Dessen P
HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43306/herc1-(hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-family-member-1)
