HIPK3 (homeodomain interacting protein kinase 3)

2006-10-01  

Identity

HGNC
HIPK3
LOCATION
11p13
LOCUSID
10114
ALIAS
DYRK6,FIST3,PKY,YAK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10114
MIM: 604424
HGNC: 4915
Ensembl: ENSG00000110422

Variants:

dbSNP: 10114
ClinVar: 10114
TCGA: ENSG00000110422
COSMIC: HIPK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110422ENST00000303296Q9H422
ENSG00000110422ENST00000379016Q9H422
ENSG00000110422ENST00000456517Q9H422
ENSG00000110422ENST00000525975Q9H422
ENSG00000110422ENST00000531504E9PKD7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
270503922016Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.519
287942022017CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.143
147667602004JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.37
203472652010MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.34
300573152018CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regulating miR-654/IGF2BP3 signaling.29
299491442018CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer.20
172106462007Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.17
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
299599222018Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis.16
287389612017[Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1].11

Citation

Dessen P

HIPK3 (homeodomain interacting protein kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43308/hipk3-(homeodomain-interacting-protein-kinase-3)