INCENP (inner centromere protein)

2006-10-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 3619
MIM: 604411
HGNC: 6058
Ensembl: ENSG00000149503

Variants:

dbSNP: 3619
ClinVar: 3619
TCGA: ENSG00000149503
COSMIC: INCENP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149503ENST00000278849Q9NQS7
ENSG00000149503ENST00000394818Q9NQS7
ENSG00000149503ENST00000533896E9PM67

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363264882023Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.0
370316752023High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.1
363264882023Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.0
370316752023High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.1
333556212021An ATM-Chk2-INCENP pathway activates the abscission checkpoint.11
333556212021An ATM-Chk2-INCENP pathway activates the abscission checkpoint.11
319431742020lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.15
319910412020Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.4
319431742020lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.15
319910412020Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.4
313060612019Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.4
314168402019Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma.8
313060612019Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.4
314168402019Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma.8
273328952016Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.9

Citation

Dessen P

INCENP (inner centromere protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43317/incenp-(inner-centromere-protein)