ITSN2 (intersectin 2)

2006-10-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
PRO2015,SH3D1B,SH3P18,SWA,SWAP
FUSION GENES

Other Information

Locus ID:

NCBI: 50618
MIM: 604464
HGNC: 6184
Ensembl: ENSG00000198399

Variants:

dbSNP: 50618
ClinVar: 50618
TCGA: ENSG00000198399
COSMIC: ITSN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198399ENST00000355123Q9NZM3
ENSG00000198399ENST00000361999Q9NZM3
ENSG00000198399ENST00000406921Q9NZM3
ENSG00000198399ENST00000412011E7EPJ2
ENSG00000198399ENST00000416160H7BZD4
ENSG00000198399ENST00000427234H7C0L8
ENSG00000198399ENST00000443927F8W719
ENSG00000198399ENST00000449392H7C3E2
ENSG00000198399ENST00000622089A0A087WVF7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163941002006Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.46
196227532009Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.19
176964072007The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.11
239362262013Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.7
224497062012Human intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation.6
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
173900672007Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.3
232744952013Crystal structure of human Intersectin-2L C2 domain.1
266333572015ITSN2L Interacts with and Negatively Regulates RABEP1.1
281616322017Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.0

Citation

Dessen P

ITSN2 (intersectin 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43330/itsn2-(intersectin-2)