Identity
HGNC
LOCATION
12q12
LOCUSID
ALIAS
AURA17,DARDARIN,PARK8,RIPK7,ROCO2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 120892
MIM: 609007
HGNC: 18618
Ensembl: ENSG00000188906
Variants:
dbSNP: 120892
ClinVar: 120892
TCGA: ENSG00000188906
COSMIC: LRRK2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Parkinson's disease | KEGG | hsa05012 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by PTK6 | REACTOME | R-HSA-8848021 |
| PTK6 promotes HIF1A stabilization | REACTOME | R-HSA-8857538 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37674036 | 2024 | A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism. | 0 |
| 38135900 | 2024 | Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease. | 0 |
| 38227290 | 2024 | The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response. | 2 |
| 38266062 | 2024 | Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study. | 0 |
| 38287861 | 2024 | The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene. | 0 |
| 38307024 | 2024 | The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons. | 0 |
| 38368930 | 2024 | VPS35 and retromer dysfunction in Parkinson's disease. | 1 |
| 38512027 | 2024 | RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors. | 1 |
| 38599001 | 2024 | Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls. | 0 |
| 38804604 | 2024 | Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant. | 0 |
| 37674036 | 2024 | A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism. | 0 |
| 38135900 | 2024 | Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease. | 0 |
| 38227290 | 2024 | The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response. | 2 |
| 38266062 | 2024 | Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study. | 0 |
| 38287861 | 2024 | The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene. | 0 |
Citation
Dessen P
LRRK2 (leucine rich repeat kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43339/
