MAP3K13 (mitogen-activated protein kinase kinase kinase 13)

2006-10-01  

Identity

HGNC
MAP3K13
LOCATION
3q27.2
LOCUSID
9175
ALIAS
LZK,MEKK13,MLK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9175
MIM: 604915
HGNC: 6852
Ensembl: ENSG00000073803

Variants:

dbSNP: 9175
ClinVar: 9175
TCGA: ENSG00000073803
COSMIC: MAP3K13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073803ENST00000265026O43283
ENSG00000073803ENST00000420577H7C459
ENSG00000073803ENST00000424227O43283
ENSG00000073803ENST00000428617C9J4W2
ENSG00000073803ENST00000433092O43283
ENSG00000073803ENST00000438053O43283
ENSG00000073803ENST00000438798C9IYH2
ENSG00000073803ENST00000439882F8WF41
ENSG00000073803ENST00000443863O43283
ENSG00000073803ENST00000446828O43283
ENSG00000073803ENST00000447637C9JP65
ENSG00000073803ENST00000448876C9IYH2
ENSG00000073803ENST00000454237C9IYH2
ENSG00000073803ENST00000455188C9IYH2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
353116292022Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.0
353116292022Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.0
311865352020The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.32
311865352020The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.32
286411132017Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.74
286411132017Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.74
269189412016microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.20
269189412016microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
121867662002Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.0
121867662002Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.0

Citation

Dessen P

MAP3K13 (mitogen-activated protein kinase kinase kinase 13)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43342/map3k13-(mitogen-activated-protein-kinase-kinase-kinase-13)