TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2)

2010-02-01 Affiliation

Identity

HGNC

TAB2

LOCATION

6q25.1

LOCUSID

23118

ALIAS

CHTD2,MAP3K7IP2,TAB-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23118
MIM: 605101
HGNC: 17075
Ensembl: ENSG00000228408

Variants:

dbSNP: 23118
ClinVar: 23118
TCGA: ENSG00000228408
COSMIC: TAB2

RNA/Proteins

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Toll-like receptor signaling pathway	KEGG	ko04620
MAPK signaling pathway	KEGG	hsa04010
Toll-like receptor signaling pathway	KEGG	hsa04620
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Toll-like receptor signaling	KEGG	hsa_M00686
Toll-like receptor signaling	KEGG	M00686
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
IRAK2 mediated activation of TAK1 complex	REACTOME	R-HSA-937042
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	REACTOME	R-HSA-445989
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	REACTOME	R-HSA-450321
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
TRAF6 mediated induction of TAK1 complex	REACTOME	R-HSA-937072
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	REACTOME	R-HSA-975163
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
NOD1/2 Signaling Pathway	REACTOME	R-HSA-168638
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Signal Transduction	REACTOME	R-HSA-162582
Signaling by ERBB4	REACTOME	R-HSA-1236394
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
TNFR1-induced NFkappaB signaling pathway	REACTOME	R-HSA-5357956
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA131301952	gefitinib	Chemical	ClinicalAnnotation	associated		PD	31664190
PA443899	Diarrhea	Disease	ClinicalAnnotation	associated		PD	31664190

References

Pubmed ID	Year	Title	Citations
15327770	2004	TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.	285
22660635	2012	The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.	144
12242293	2002	Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.	91
19935683	2009	Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.	80
15590691	2005	Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.	78
22158122	2011	Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation.	62
17158449	2007	TAK1-dependent signaling requires functional interaction with TAB2/TAB3.	53
21035162	2011	Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition.	40
22081109	2011	Inhibition of autophagy by TAB2 and TAB3.	40
24434549	2014	TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.	37

Citation

Dessen P

TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/43345/tab2-(tgf-beta-activated-kinase-1-(map3k7)-binding-protein-2)