Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11184
MIM: 601983
HGNC: 6863
Ensembl: ENSG00000104814
Variants:
dbSNP: 11184
ClinVar: 11184
TCGA: ENSG00000104814
COSMIC: MAP4K1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK signaling pathway | KEGG | ko04010 |
| MAPK signaling pathway | KEGG | hsa04010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37734869 | 2023 | Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration. | 1 |
| 37734869 | 2023 | Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration. | 1 |
| 35099066 | 2022 | Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: A proteomic approach. | 1 |
| 35099066 | 2022 | Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: A proteomic approach. | 1 |
| 33439152 | 2021 | Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1). | 2 |
| 34166980 | 2021 | MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway. | 8 |
| 34908452 | 2021 | The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε. | 8 |
| 33439152 | 2021 | Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1). | 2 |
| 34166980 | 2021 | MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway. | 8 |
| 34908452 | 2021 | The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε. | 8 |
| 31959629 | 2020 | Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer. | 6 |
| 32640226 | 2020 | MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. | 30 |
| 32860752 | 2020 | Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. | 53 |
| 31959629 | 2020 | Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer. | 6 |
| 32640226 | 2020 | MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. | 30 |
Citation
Dessen P
MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43346/map4k1-(mitogen-activated-protein-kinase-kinase-kinase-kinase-1)
