Identity
HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
BL44,GCK,RAB8IP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5871
MIM: 603166
HGNC: 6864
Ensembl: ENSG00000168067
Variants:
dbSNP: 5871
ClinVar: 5871
TCGA: ENSG00000168067
COSMIC: MAP4K2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK signaling pathway | KEGG | ko04010 |
| MAPK signaling pathway | KEGG | hsa04010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37937799 | 2024 | MAP4K2 connects the Hippo pathway to autophagy in response to energy stress. | 0 |
| 37937799 | 2024 | MAP4K2 connects the Hippo pathway to autophagy in response to energy stress. | 0 |
| 30217450 | 2018 | Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis. | 13 |
| 30217450 | 2018 | Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis. | 13 |
| 27151888 | 2016 | Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma. | 13 |
| 27151888 | 2016 | Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma. | 13 |
| 25075558 | 2015 | Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). | 32 |
| 25075558 | 2015 | Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). | 32 |
| 24072714 | 2013 | Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB. | 33 |
| 24072714 | 2013 | Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB. | 33 |
| 22433857 | 2012 | A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis. | 78 |
| 22433857 | 2012 | A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis. | 78 |
| 20332113 | 2010 | CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. | 66 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20332113 | 2010 | CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. | 66 |
Citation
Dessen P
MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43347/map4k2-(mitogen-activated-protein-kinase-kinase-kinase-kinase-2)
