NEK7 (NIMA related kinase 7)

2006-10-01  

Identity

HGNC
LOCATION
1q31.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 140609
MIM: 606848
HGNC: 13386
Ensembl: ENSG00000151414

Variants:

dbSNP: 140609
ClinVar: 140609
TCGA: ENSG00000151414
COSMIC: NEK7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151414ENST00000367383Q8TDX7
ENSG00000151414ENST00000367385Q8TDX7
ENSG00000151414ENST00000367385A0A024R964
ENSG00000151414ENST00000391974F8WAG2
ENSG00000151414ENST00000442588C9J1H8
ENSG00000151414ENST00000538004Q8TDX7
ENSG00000151414ENST00000538004A0A024R964
ENSG00000151414ENST00000544035F5H3U7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
266423562016NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.110
128400242003A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.60
194145962009The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.60
216429572011Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.57
171011322006Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.42
199418172009An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.40
252809692015WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.31
175864732007NEK7 is a centrosomal kinase critical for microtubule nucleation.27
311899532019Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.23
238217722013A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.22

Citation

Dessen P

NEK7 (NIMA related kinase 7)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43375/nek7-(nima-related-kinase-7)