Identity
HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
JCK,NEK12A,NPHP9,RHPD2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 284086
MIM: 609799
HGNC: 13387
Ensembl: ENSG00000160602
Variants:
dbSNP: 284086
ClinVar: 284086
TCGA: ENSG00000160602
COSMIC: NEK8
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37596667 | 2023 | NEK8 regulates colorectal cancer progression via phosphorylating MYC. | 1 |
| 37598857 | 2023 | Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease. | 3 |
| 37596667 | 2023 | NEK8 regulates colorectal cancer progression via phosphorylating MYC. | 1 |
| 37598857 | 2023 | Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease. | 3 |
| 31633649 | 2020 | Homozygous NEK8 Mutations in Siblings With Neonatal Cholestasis Progressing to End-stage Liver, Renal, and Cardiac Disease. | 2 |
| 31633649 | 2020 | Homozygous NEK8 Mutations in Siblings With Neonatal Cholestasis Progressing to End-stage Liver, Renal, and Cardiac Disease. | 2 |
| 27892797 | 2017 | NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection. | 15 |
| 27892797 | 2017 | NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection. | 15 |
| 26697755 | 2016 | Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. | 13 |
| 26967905 | 2016 | Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. | 46 |
| 26697755 | 2016 | Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. | 13 |
| 26967905 | 2016 | Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. | 46 |
| 25451921 | 2015 | The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells. | 21 |
| 25451921 | 2015 | The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells. | 21 |
| 23418306 | 2013 | Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression. | 47 |
Citation
Dessen P
NEK8 (NIMA related kinase 8)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43376/nek8-(nima-related-kinase-8)
