Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4999
MIM: 601182
HGNC: 8488
Ensembl: ENSG00000115942
Variants:
dbSNP: 4999
ClinVar: 4999
TCGA: ENSG00000115942
COSMIC: ORC2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115942 | ENST00000234296 | Q13416 |
| ENSG00000115942 | ENST00000234296 | A0A024R411 |
| ENSG00000115942 | ENST00000410039 | B8ZZ80 |
| ENSG00000115942 | ENST00000457595 | C9JK08 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32989049 | 2020 | A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins. | 15 |
| 32989049 | 2020 | A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins. | 15 |
| 31103262 | 2019 | Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth. | 16 |
| 31103262 | 2019 | Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth. | 16 |
| 27052177 | 2016 | SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. | 27 |
| 27701460 | 2016 | The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. | 17 |
| 27906128 | 2016 | Two subunits of human ORC are dispensable for DNA replication and proliferation. | 25 |
| 27052177 | 2016 | SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. | 27 |
| 27701460 | 2016 | The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. | 17 |
| 27906128 | 2016 | Two subunits of human ORC are dispensable for DNA replication and proliferation. | 25 |
| 24732362 | 2014 | Protein phosphatase 1 dephosphorylates Orc2. | 0 |
| 24792176 | 2014 | Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin. | 2 |
| 24732362 | 2014 | Protein phosphatase 1 dephosphorylates Orc2. | 0 |
| 24792176 | 2014 | Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin. | 2 |
| 23188630 | 2013 | Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer. | 48 |
Citation
Dessen P
ORC2 (origin recognition complex subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43387/orc2-(origin-recognition-complex-subunit-2)
