PAK4 (p21 (RAC1) activated kinase 4)

2006-10-01  

Identity

HGNC
PAK4
LOCATION
19q13.2
LOCUSID
10298
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10298
MIM: 605451
HGNC: 16059
Ensembl: ENSG00000130669

Variants:

dbSNP: 10298
ClinVar: 10298
TCGA: ENSG00000130669
COSMIC: PAK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130669ENST00000321944O96013
ENSG00000130669ENST00000358301O96013
ENSG00000130669ENST00000358301A0A024R0J1
ENSG00000130669ENST00000360442O96013
ENSG00000130669ENST00000360442A0A024R0J1
ENSG00000130669ENST00000593480M0R2X4
ENSG00000130669ENST00000593690O96013
ENSG00000130669ENST00000593690A0A024R0J1
ENSG00000130669ENST00000597715M0R1R1
ENSG00000130669ENST00000599386O96013
ENSG00000130669ENST00000599386A0A024R0L8
ENSG00000130669ENST00000599470O96013
ENSG00000130669ENST00000599470A0A024R0L8
ENSG00000130669ENST00000599657M0R3G6
ENSG00000130669ENST00000602004M0R0L9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
T cell receptor signaling pathwayKEGGko04660
Regulation of actin cytoskeletonKEGGko04810
Renal cell carcinomaKEGGko05211
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
T cell receptor signaling pathwayKEGGhsa04660
Regulation of actin cytoskeletonKEGGhsa04810
Renal cell carcinomaKEGGhsa05211
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183193012008Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.92
209267452010p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.76
158270852005PAK4 mediates morphological changes through the regulation of GEF-H1.74
190500742008Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.59
252382882014p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway.56
184240722008A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.54
188362862008Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification.52
226534412012Group I and II mammalian PAKs have different modes of activation by Cdc42.43
204068872010PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.41
243743102014Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.41

Citation

Dessen P

PAK4 (p21 (RAC1) activated kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43393/pak4-(p21-(rac1)-activated-kinase-4)