PAK4 (p21 (RAC1) activated kinase 4)

2006-10-01  

Identity

HGNC
PAK4
LOCATION
19q13.2
LOCUSID
10298
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10298
MIM: 605451
HGNC: 16059
Ensembl: ENSG00000130669

Variants:

dbSNP: 10298
ClinVar: 10298
TCGA: ENSG00000130669
COSMIC: PAK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130669ENST00000321944O96013
ENSG00000130669ENST00000358301O96013
ENSG00000130669ENST00000358301A0A024R0J1
ENSG00000130669ENST00000360442O96013
ENSG00000130669ENST00000360442A0A024R0J1
ENSG00000130669ENST00000593480M0R2X4
ENSG00000130669ENST00000593690O96013
ENSG00000130669ENST00000593690A0A024R0J1
ENSG00000130669ENST00000597715M0R1R1
ENSG00000130669ENST00000599386O96013
ENSG00000130669ENST00000599386A0A024R0L8
ENSG00000130669ENST00000599470O96013
ENSG00000130669ENST00000599470A0A024R0L8
ENSG00000130669ENST00000599657M0R3G6
ENSG00000130669ENST00000602004M0R0L9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
T cell receptor signaling pathwayKEGGko04660
Regulation of actin cytoskeletonKEGGko04810
Renal cell carcinomaKEGGko05211
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
T cell receptor signaling pathwayKEGGhsa04660
Regulation of actin cytoskeletonKEGGhsa04810
Renal cell carcinomaKEGGhsa05211
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364705412023Pan-cancer analysis identifies the immunological and prognostic role of PAK4.1
365933832023The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.0
364705412023Pan-cancer analysis identifies the immunological and prognostic role of PAK4.1
365933832023The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.0
337653672022miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.1
357980862022PAK4 in cancer development: Emerging player and therapeutic opportunities.2
358835752022Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.1
359842042022PAK4 expression is associated with the prognosis in non-small cell lung cancer.0
337653672022miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.1
357980862022PAK4 in cancer development: Emerging player and therapeutic opportunities.2
358835752022Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.1
359842042022PAK4 expression is associated with the prognosis in non-small cell lung cancer.0
331686462021Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma.15
334144912021p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.6
337106052021Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA.2

Citation

Dessen P

PAK4 (p21 (RAC1) activated kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43393/pak4-(p21-(rac1)-activated-kinase-4)