CDK16 (cyclin dependent kinase 16)

2006-10-01  

Identity

HGNC
CDK16
LOCATION
Xp11.3
LOCUSID
5127
ALIAS
PCTAIRE,PCTAIRE1,PCTGAIRE,PCTK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5127
MIM: 311550
HGNC: 8749
Ensembl: ENSG00000102225

Variants:

dbSNP: 5127
ClinVar: 5127
TCGA: ENSG00000102225
COSMIC: CDK16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102225ENST00000276052Q00536
ENSG00000102225ENST00000357227Q00536
ENSG00000102225ENST00000357227A0A140VK97
ENSG00000102225ENST00000457458Q00536
ENSG00000102225ENST00000457458A0A024R183
ENSG00000102225ENST00000462827H0YC36
ENSG00000102225ENST00000517426E5RGN0
ENSG00000102225ENST00000518022Q00536
ENSG00000102225ENST00000518022A0A140VK97
ENSG00000102225ENST00000518391E5RJM2
ENSG00000102225ENST00000519758E5RIY8
ENSG00000102225ENST00000520141H0YC60
ENSG00000102225ENST00000520295E5RGV7
ENSG00000102225ENST00000520893E5RIU4
ENSG00000102225ENST00000522883E5RJQ8
ENSG00000102225ENST00000523034H0YBX5
ENSG00000102225ENST00000523344H0YAZ9
ENSG00000102225ENST00000622098A0A087WZU2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372360282023The roles, molecular interactions, and therapeutic value of CDK16 in human cancers.3
373731552023PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation, Stemness, and Chemoresistance in Colorectal Cancer through the BMPR1B-Smad1/5/8 Signaling Pathway.1
372360282023The roles, molecular interactions, and therapeutic value of CDK16 in human cancers.3
373731552023PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation, Stemness, and Chemoresistance in Colorectal Cancer through the BMPR1B-Smad1/5/8 Signaling Pathway.1
346872702022Lung cancer cells expressing a shortened CDK16 3'UTR escape senescence through impaired miR-485-5p targeting.5
354490802022CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1.12
346872702022Lung cancer cells expressing a shortened CDK16 3'UTR escape senescence through impaired miR-485-5p targeting.5
354490802022CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1.12
318825542020Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC.10
320989612020AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy.19
331352902020circRNA 001306 enhances hepatocellular carcinoma growth by up-regulating CDK16 expression via sponging miR-584-5p.14
318825542020Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC.10
320989612020AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy.19
331352902020circRNA 001306 enhances hepatocellular carcinoma growth by up-regulating CDK16 expression via sponging miR-584-5p.14
304114962019Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell.32

Citation

Dessen P

CDK16 (cyclin dependent kinase 16)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43396/cdk16-(cyclin-dependent-kinase-16)