PDK1 (pyruvate dehydrogenase kinase 1)

2006-10-01  

Identity

HGNC
PDK1
LOCATION
2q31.1
LOCUSID
5163
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5163
MIM: 602524
HGNC: 8809
Ensembl: ENSG00000152256

Variants:

dbSNP: 5163
ClinVar: 5163
TCGA: ENSG00000152256
COSMIC: PDK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152256ENST00000282077Q15118
ENSG00000152256ENST00000392571Q15118
ENSG00000152256ENST00000410055Q15118
ENSG00000152256ENST00000416991C9IYB4
ENSG00000152256ENST00000431718F8WEJ6
ENSG00000152256ENST00000436490F8WC75
ENSG00000152256ENST00000439519C9JKT3
ENSG00000152256ENST00000443353C9JKT3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HIF-1 signaling pathwayKEGGhsa04066
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24684AKT1GenePathwayassociated22336956
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
379053402024RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.0
381995642024Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression.0
383533582024Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.0
387331792024Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis.1
379053402024RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.0
381995642024Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression.0
383533582024Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.0
387331792024Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis.1
363312852023Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression.0
363348052023CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis.3
368664362023Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.11
369883472023PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.1
370143172023Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy.2
370425732023PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.0
371416972023Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling.1

Citation

Dessen P

PDK1 (pyruvate dehydrogenase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43405