CDK14 (cyclin dependent kinase 14)

2006-10-01  

Identity

HGNC
CDK14
LOCATION
7q21.13
LOCUSID
5218
ALIAS
PFTAIRE1,PFTK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5218
MIM: 610679
HGNC: 8883
Ensembl: ENSG00000058091

Variants:

dbSNP: 5218
ClinVar: 5218
TCGA: ENSG00000058091
COSMIC: CDK14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058091ENST00000265741O94921
ENSG00000058091ENST00000380050O94921
ENSG00000058091ENST00000406263O94921
ENSG00000058091ENST00000430760C9IYJ9
ENSG00000058091ENST00000431029F8WF96
ENSG00000058091ENST00000436577E7EUK8
ENSG00000058091ENST00000446224C9IYJ9
ENSG00000058091ENST00000446790C9JWL6
ENSG00000058091ENST00000449528C9IYJ9
ENSG00000058091ENST00000456689C9IYJ9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385756012024Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.1
385756012024Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.1
375993592023P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.5
375993592023P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.5
337647142022LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.7
350025292022CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.19
337647142022LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.7
350025292022CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.19
332175952021MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.2
343484652021Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.3
332175952021MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.2
343484652021Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.3
326055632020Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway.7
328021822020CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.37
326055632020Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway.7

Citation

Dessen P

CDK14 (cyclin dependent kinase 14)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43407/cdk14-(cyclin-dependent-kinase-14)