POLA2 (DNA polymerase alpha 2, accessory subunit)

2006-10-01  

Identity

HGNC
POLA2
LOCATION
11q13.1
LOCUSID
23649
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23649
HGNC: 30073
Ensembl: ENSG00000285816

Variants:

dbSNP: 23649
ClinVar: 23649
TCGA: ENSG00000285816
COSMIC: POLA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000285816ENST00000649896A0A3B3ITS5

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Metabolic pathwaysKEGGhsa01100
DNA polymerase alpha / primase complexKEGGhsa_M00261
DNA polymerase alpha / primase complexKEGGM00261
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
Inhibition of replication initiation of damaged DNA by RB1/E2F1REACTOMER-HSA-113501
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA replication initiationREACTOMER-HSA-68952
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Removal of the Flap IntermediateREACTOMER-HSA-69166
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Telomere C-strand synthesis initiationREACTOMER-HSA-174430
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306

References

Pubmed IDYearTitleCitations
367306132023CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma.0
367306132023CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma.0
325491882020Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress.6
325491882020Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress.6
289344862017STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.34
289344862017STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.34
281556582016Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells.8
281556582016Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells.8
255216642014Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.4
255216642014Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.4
225935762012A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.27
225935762012A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.27
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
192376062009Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.14

Citation

Dessen P

POLA2 (DNA polymerase alpha 2, accessory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43415/pola2-(dna-polymerase-alpha-2-accessory-subunit)