POLE4 (DNA polymerase epsilon 4, accessory subunit)

2006-10-01 Affiliation

Identity

HGNC

POLE4

LOCATION

2p12

LOCUSID

56655

ALIAS

YHHQ1,p12

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 56655
MIM: 607269
HGNC: 18755
Ensembl: ENSG00000115350

Variants:

dbSNP: 56655
ClinVar: 56655
TCGA: ENSG00000115350
COSMIC: POLE4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115350	ENST00000483063	Q9NR33

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
DNA replication	KEGG	ko03030
Base excision repair	KEGG	ko03410
Nucleotide excision repair	KEGG	ko03420
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
DNA replication	KEGG	hsa03030
Base excision repair	KEGG	hsa03410
Nucleotide excision repair	KEGG	hsa03420
Metabolic pathways	KEGG	hsa01100
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
DNA polymerase epsilon complex	KEGG	hsa_M00263
DNA polymerase epsilon complex	KEGG	M00263
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1/S Transition	REACTOME	R-HSA-69206
Activation of the pre-replicative complex	REACTOME	R-HSA-68962
S Phase	REACTOME	R-HSA-69242
Synthesis of DNA	REACTOME	R-HSA-69239
DNA replication initiation	REACTOME	R-HSA-68952
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
Chromosome Maintenance	REACTOME	R-HSA-73886
Telomere Maintenance	REACTOME	R-HSA-157579
Extension of Telomeres	REACTOME	R-HSA-180786
Telomere C-strand (Lagging Strand) Synthesis	REACTOME	R-HSA-174417
Telomere C-strand synthesis initiation	REACTOME	R-HSA-174430
DNA Replication	REACTOME	R-HSA-69306
DNA Repair	REACTOME	R-HSA-73894
Base Excision Repair	REACTOME	R-HSA-73884
Resolution of Abasic Sites (AP sites)	REACTOME	R-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	REACTOME	R-HSA-110373
PCNA-Dependent Long Patch Base Excision Repair	REACTOME	R-HSA-5651801
DNA Damage Bypass	REACTOME	R-HSA-73893
Recognition of DNA damage by PCNA-containing replication complex	REACTOME	R-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Termination of translesion DNA synthesis	REACTOME	R-HSA-5656169
DNA Double-Strand Break Repair	REACTOME	R-HSA-5693532
Homology Directed Repair	REACTOME	R-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	REACTOME	R-HSA-5693567
HDR through Homologous Recombination (HRR)	REACTOME	R-HSA-5685942
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)	REACTOME	R-HSA-5696399
Dual Incision in GG-NER	REACTOME	R-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NER	REACTOME	R-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	REACTOME	R-HSA-6781827
Dual incision in TC-NER	REACTOME	R-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NER	REACTOME	R-HSA-6782210

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
30217558	2018	POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.	16

Citation

Dessen P

POLE4 (DNA polymerase epsilon 4, accessory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43419/pole4-(dna-polymerase-epsilon-4-accessory-subunit)