POT1 (protection of telomeres 1)

2006-10-01  

Identity

HGNC
LOCATION
7q31.33
LOCUSID
ALIAS
CMM10,GLM9,HPOT1

Other Information

Locus ID:

NCBI: 25913
MIM: 606478
HGNC: 17284
Ensembl: ENSG00000128513

Variants:

dbSNP: 25913
ClinVar: 25913
TCGA: ENSG00000128513
COSMIC: POT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128513ENST00000357628Q9NUX5
ENSG00000128513ENST00000357628A0A024R739
ENSG00000128513ENST00000393329A8MTK3
ENSG00000128513ENST00000429326Q5MJ33
ENSG00000128513ENST00000430927Q5MJ34
ENSG00000128513ENST00000446993C9JPG9
ENSG00000128513ENST00000607932Q5MJ34
ENSG00000128513ENST00000608057Q5MJ35
ENSG00000128513ENST00000609106B7Z7M5
ENSG00000128513ENST00000609702V9GZ00
ENSG00000128513ENST00000653241Q9NUX5
ENSG00000128513ENST00000653241A0A024R739
ENSG00000128513ENST00000653274A0A590UJF2
ENSG00000128513ENST00000653819Q5MJ33
ENSG00000128513ENST00000653892Q5MJ33
ENSG00000128513ENST00000654766A0A590UJF7
ENSG00000128513ENST00000655761Q9NUX5
ENSG00000128513ENST00000655761A0A024R739
ENSG00000128513ENST00000657333Q5MJ33
ENSG00000128513ENST00000657892A0A590UJR1
ENSG00000128513ENST00000661898A0A590UJP0
ENSG00000128513ENST00000662531A0A590UJM4
ENSG00000128513ENST00000664330Q5MJ33
ENSG00000128513ENST00000664366Q9NUX5
ENSG00000128513ENST00000664366A0A024R739
ENSG00000128513ENST00000668382Q9NUX5
ENSG00000128513ENST00000668382A0A024R739

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Shelterin complexKEGGhsa_M00424
Shelterin complexKEGGM00424
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Packaging Of Telomere EndsREACTOMER-HSA-171306
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586

References

Pubmed IDYearTitleCitations
382549932024Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition Syndrome.1
384292702024Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1.0
385404142024A POT1 Founder Variant Associated with Early Onset Recurrent Melanoma and Various Solid Malignancies.0
382549932024Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition Syndrome.1
384292702024Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1.0
385404142024A POT1 Founder Variant Associated with Early Onset Recurrent Melanoma and Various Solid Malignancies.0
371401662023Familial Clonal Hematopoiesis in a Long Telomere Syndrome.28
371833252023POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.4
374660572023Characterization of POT1 tumor predisposition syndrome: Tumor prevalence in a clinically diverse hereditary cancer cohort.3
375903462023Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.7
377701502023POT1 involved in telomeric DNA damage repair and genomic stability of cervical cancer cells in response to radiation.1
371401662023Familial Clonal Hematopoiesis in a Long Telomere Syndrome.28
371833252023POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.4
374660572023Characterization of POT1 tumor predisposition syndrome: Tumor prevalence in a clinically diverse hereditary cancer cohort.3
375903462023Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.7

Citation

Dessen P

POT1 (protection of telomeres 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43423