Identity
HGNC
LOCATION
17q22
LOCUSID
ALIAS
CAMKPN,CaMKP-N,POPX1,PP2CH,caMKN
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22843
HGNC: 19322
Ensembl: ENSG00000175175
Variants:
dbSNP: 22843
ClinVar: 22843
TCGA: ENSG00000175175
COSMIC: PPM1E
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000175175 | ENST00000308249 | Q8WY54 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36662636 | 2023 | Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes. | 1 |
| 36662636 | 2023 | Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes. | 1 |
| 28423719 | 2017 | AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation. | 16 |
| 28460435 | 2017 | microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation. | 8 |
| 28423719 | 2017 | AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation. | 16 |
| 28460435 | 2017 | microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation. | 8 |
| 27661114 | 2016 | miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone. | 29 |
| 27793001 | 2016 | miR-135b-5p inhibits LPS-induced TNFα production via silencing AMPK phosphatase Ppm1e. | 22 |
| 27661114 | 2016 | miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone. | 29 |
| 27793001 | 2016 | miR-135b-5p inhibits LPS-induced TNFα production via silencing AMPK phosphatase Ppm1e. | 22 |
| 20801214 | 2011 | Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. | 45 |
| 20801214 | 2011 | Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. | 45 |
| 11864573 | 2002 | The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. | 48 |
| 11864573 | 2002 | The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. | 48 |
Citation
Dessen P
PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43424/ppm1e-(protein-phosphatase-mg2+-mn2+-dependent-1e)
