PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)

2006-10-01  

Identity

HGNC
PREX1
LOCATION
20q13.13
LOCUSID
57580
ALIAS
P-REX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57580
MIM: 606905
HGNC: 32594
Ensembl: ENSG00000124126

Variants:

dbSNP: 57580
ClinVar: 57580
TCGA: ENSG00000124126
COSMIC: PREX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124126ENST00000371941Q8TCU6
ENSG00000124126ENST00000482556H0YDZ4
ENSG00000124126ENST00000620554A0A087WY11

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383298132024PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age.0
383298132024PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age.0
374344022023Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1.1
374344022023Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1.1
358641642022Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.4
358641642022Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.4
334124172021Gβγ recruits and activates P-Rex1 via two independent binding interfaces.3
346243162021Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.0
334124172021Gβγ recruits and activates P-Rex1 via two independent binding interfaces.3
346243162021Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.0
316363892020PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells.15
326611982020The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.5
327858732020Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis.3
316363892020PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells.15
326611982020The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.5

Citation

Dessen P

PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43426/prex1-(phosphatidylinositol-3-4-5-trisphosphate-dependent-rac-exchange-factor-1)