CYTH1 (cytohesin 1)

2006-10-01  

Identity

HGNC
CYTH1
LOCATION
17q25.3
LOCUSID
9267
ALIAS
B2-1,CYTOHESIN-1,D17S811E,PSCD1,SEC7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9267
MIM: 182115
HGNC: 9501
Ensembl: ENSG00000108669

Variants:

dbSNP: 9267
ClinVar: 9267
TCGA: ENSG00000108669
COSMIC: CYTH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108669ENST00000361101Q15438
ENSG00000108669ENST00000446868Q15438
ENSG00000108669ENST00000585509Q15438
ENSG00000108669ENST00000586043K7ERV8
ENSG00000108669ENST00000587308K7EKA2
ENSG00000108669ENST00000589296K7EJN5
ENSG00000108669ENST00000589297Q15438
ENSG00000108669ENST00000589768K7ENQ8
ENSG00000108669ENST00000590300K7ENH6
ENSG00000108669ENST00000591455Q15438
ENSG00000108669ENST00000591574K7EL72

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

References

Pubmed IDYearTitleCitations
304049492019HGF-induced migration depends on the PI(3,4,5)P(3)-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.15
309431062019Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.7
304049492019HGF-induced migration depends on the PI(3,4,5)P(3)-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.15
309431062019Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.7
287807512018Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.3
287807512018Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.3
278993582017Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.10
278993582017Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.10
270447542016FRMD4A-cytohesin signaling modulates the cellular release of tau.23
270447542016FRMD4A-cytohesin signaling modulates the cellular release of tau.23
228159592012Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.13
228159592012Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.13
215113402011Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.12
215113402011Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.12
200186262010Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.9

Citation

Dessen P

CYTH1 (cytohesin 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43432/cyth1-(cytohesin-1)