ARHGAP32 (Rho GTPase activating protein 32)

2006-10-01  

Identity

HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
GC-GAP,GRIT,PX-RICS,RICS,p200RhoGAP,p250GAP
FUSION GENES

Other Information

Locus ID:

NCBI: 9743
MIM: 608541
HGNC: 17399
Ensembl: ENSG00000134909

Variants:

dbSNP: 9743
ClinVar: 9743
TCGA: ENSG00000134909
COSMIC: ARHGAP32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134909ENST00000310343A7KAX9
ENSG00000134909ENST00000392657A7KAX9
ENSG00000134909ENST00000524655G3V174
ENSG00000134909ENST00000525234E9PRH3
ENSG00000134909ENST00000527272A7KAX9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185775892008An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.260
124773922002Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.62
125319012003RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.50
128578752003p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.36
128578752003p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.36
124467892002Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.35
124540182003Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP.23
128192032003GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.23
127880812003p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.19
184511112008PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.16

Citation

Dessen P

ARHGAP32 (Rho GTPase activating protein 32)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43468/arhgap32-(rho-gtpase-activating-protein-32)