SIK1 (salt inducible kinase 1)

2006-10-01 Affiliation

Identity

HGNC

SIK1

LOCATION

21q22.3

LOCUSID

150094

ALIAS

DEE30,MSK,SIK,SIK-1,SIK1B,SNF1LK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 150094
MIM: 605705
HGNC: 11142
Ensembl: ENSG00000142178

Variants:

dbSNP: 150094
ClinVar: 150094
TCGA: ENSG00000142178
COSMIC: SIK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000142178	ENST00000270162	P57059
ENSG00000142178	ENST00000644750	A0A2R8Y6E4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Circadian Clock	REACTOME	R-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expression	REACTOME	R-HSA-1368108

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37116165	2023	Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients.	0
37556419	2023	Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health.	0
37116165	2023	Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients.	0
37556419	2023	Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health.	0
34384713	2022	Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis.	10
34983607	2022	Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.	7
34384713	2022	Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis.	10
34983607	2022	Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.	7
33588892	2021	Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.	5
33588892	2021	Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.	5
32483145	2020	Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.	18
33013689	2020	SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.	7
32483145	2020	Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.	18
33013689	2020	SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.	7
31350327	2019	An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.	43

Citation

Dessen P

SIK1 (salt inducible kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43496/sik1-(salt-inducible-kinase-1)