SRPK1 (SRSF protein kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
SFRSK1
FUSION GENES

Other Information

Locus ID:

NCBI: 6732
MIM: 601939
HGNC: 11305
Ensembl: ENSG00000096063

Variants:

dbSNP: 6732
ClinVar: 6732
TCGA: ENSG00000096063
COSMIC: SRPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096063ENST00000361690H3BLV9
ENSG00000096063ENST00000373825Q96SB4
ENSG00000096063ENST00000423325Q96SB4
ENSG00000096063ENST00000507292H0Y932
ENSG00000096063ENST00000507909D6RB98
ENSG00000096063ENST00000508473D6RDZ3
ENSG00000096063ENST00000510290D6RBF8
ENSG00000096063ENST00000512445D6RBM8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227276682012The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.102
221727222011WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.88
192401342009Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.71
173323362007Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121340182002Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.54
183426042008A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.51
253818162015Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.51
257745022015Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.46
162237272005Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty.41

Citation

Dessen P

SRPK1 (SRSF protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43505/srpk1-(srsf-protein-kinase-1)