STK39 (serine/threonine kinase 39)

2006-10-01  

Identity

HGNC
LOCATION
2q24.3
LOCUSID
ALIAS
DCHT,PASK,SPAK
FUSION GENES

Other Information

Locus ID:

NCBI: 27347
MIM: 607648
HGNC: 17717
Ensembl: ENSG00000198648

Variants:

dbSNP: 27347
ClinVar: 27347
TCGA: ENSG00000198648
COSMIC: STK39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198648ENST00000355999Q9UEW8

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134875400WNK4GenePathwayassociated23788015
PA134973207OXSR1GenePathwayassociated23788015
PA321SLC12A3GenePathwayassociated23788015
PA33782WNK1GenePathwayassociated23788015
PA33784WNK3GenePathwayassociated23788015
PA450268losartanChemicalClinicalAnnotationassociatedPD21993215

References

Pubmed IDYearTitleCitations
162637222005WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.168
182702622008Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.148
191146572009From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.120
191146572009From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.120
166697872006Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.96
127403792003PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
213213282011Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.61
243930352014The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.58
194146792009Genome-wide analysis of survival in early-stage non-small-cell lung cancer.49

Citation

Dessen P

STK39 (serine/threonine kinase 39)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43518/stk39-(serine-threonine-kinase-39)