TLK1 (tousled like kinase 1)

2006-10-01  

Identity

HGNC
TLK1
LOCATION
2q31.1
LOCUSID
9874
ALIAS
PKU-beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9874
MIM: 608438
HGNC: 11841
Ensembl: ENSG00000198586

Variants:

dbSNP: 9874
ClinVar: 9874
TCGA: ENSG00000198586
COSMIC: TLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198586ENST00000359766F8W7X8
ENSG00000198586ENST00000409443B3KRP1
ENSG00000198586ENST00000431350Q9UKI8
ENSG00000198586ENST00000453628C9JWT6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
384980252024The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.0
384980252024The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.0
369470602023The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.2
374621402023CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.1
376861732023Untousling the Role of Tousled-like Kinase 1 in DNA Damage Repair.2
369470602023The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.2
374621402023CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.1
376861732023Untousling the Role of Tousled-like Kinase 1 in DNA Damage Repair.2
347313872022CircTLK1 Downregulation Attenuates High Glucose-Induced Human Mesangial Cell Injury by Blocking the AKT/NF-κB Pathway Through Sponging miR-126-5p/miR-204-5p.7
350646192022TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies.5
347313872022CircTLK1 Downregulation Attenuates High Glucose-Induced Human Mesangial Cell Injury by Blocking the AKT/NF-κB Pathway Through Sponging miR-126-5p/miR-204-5p.7
350646192022TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies.5
344106822021CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.14
344106822021CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.14
313625192020Variation analysis of tousled like kinase 1 gene in patients with sporadic premature ovarian insufficiency.0

Citation

Dessen P

TLK1 (tousled like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43529/tlk1-(tousled-like-kinase-1)