TOP3A (DNA topoisomerase III alpha)

2006-10-01  

Identity

HGNC
TOP3A
LOCATION
17p11.2
LOCUSID
7156
ALIAS
MGRISCE2,PEOB5,TOP3,ZGRF7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7156
MIM: 601243
HGNC: 11992
Ensembl: ENSG00000177302

Variants:

dbSNP: 7156
ClinVar: 7156
TCGA: ENSG00000177302
COSMIC: TOP3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177302ENST00000321105Q13472
ENSG00000177302ENST00000461127J3QR18
ENSG00000177302ENST00000489131K7EL07
ENSG00000177302ENST00000493648K7EJ41
ENSG00000177302ENST00000542570Q13472
ENSG00000177302ENST00000580095Q13472
ENSG00000177302ENST00000581536K7EMT6
ENSG00000177302ENST00000582122K7ELI7
ENSG00000177302ENST00000582981J3KS96
ENSG00000177302ENST00000584582J3KRR9
ENSG00000177302ENST00000585031J3QS25

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Bloom's syndrome complexKEGGhsa_M00414
Bloom's syndrome complexKEGGM00414
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350320742023Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.3
365292882023The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins.3
370136092023Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.7
350320742023Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.3
365292882023The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins.3
370136092023Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.7
351021512022Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.6
351155252022The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops.4
359200012022TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.13
362150392022Two type I topoisomerases maintain DNA topology in human mitochondria.6
351021512022Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.6
351155252022The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops.4
359200012022TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.13
362150392022Two type I topoisomerases maintain DNA topology in human mitochondria.6
336313202021Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.8

Citation

Dessen P

TOP3A (DNA topoisomerase III alpha)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43536/top3a-(dna-topoisomerase-iii-alpha)