Identity
HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
MGRISCE2,PEOB5,TOP3,ZGRF7
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7156
MIM: 601243
HGNC: 11992
Ensembl: ENSG00000177302
Variants:
dbSNP: 7156
ClinVar: 7156
TCGA: ENSG00000177302
COSMIC: TOP3A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35032074 | 2023 | Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy. | 3 |
| 36529288 | 2023 | The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins. | 3 |
| 37013609 | 2023 | Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. | 7 |
| 35032074 | 2023 | Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy. | 3 |
| 36529288 | 2023 | The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins. | 3 |
| 37013609 | 2023 | Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. | 7 |
| 35102151 | 2022 | Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex. | 6 |
| 35115525 | 2022 | The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops. | 4 |
| 35920001 | 2022 | TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT. | 13 |
| 36215039 | 2022 | Two type I topoisomerases maintain DNA topology in human mitochondria. | 6 |
| 35102151 | 2022 | Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex. | 6 |
| 35115525 | 2022 | The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops. | 4 |
| 35920001 | 2022 | TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT. | 13 |
| 36215039 | 2022 | Two type I topoisomerases maintain DNA topology in human mitochondria. | 6 |
| 33631320 | 2021 | Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder. | 8 |
Citation
Dessen P
TOP3A (DNA topoisomerase III alpha)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43536/top3a-(dna-topoisomerase-iii-alpha)
