TP53RK (TP53 regulating kinase)

2006-10-01 Affiliation

Identity

HGNC

TP53RK

LOCATION

20q13.12

LOCUSID

112858

ALIAS

BUD32,C20orf64,GAMOS4,Nori-2,Nori-2p,PRPK,TPRKB,dJ101A2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 112858
MIM: 608679
HGNC: 16197
Ensembl: ENSG00000172315

Variants:

dbSNP: 112858
ClinVar: 112858
TCGA: ENSG00000172315
COSMIC: TP53RK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172315	ENST00000372102	Q5JZ02
ENSG00000172315	ENST00000372114	Q96S44

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
tRNA processing	REACTOME	R-HSA-72306
tRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6782315
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37382161	2023	TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.	0
37382161	2023	TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.	0
33547416	2021	Crystal structure of the human PRPK-TPRKB complex.	6
33547416	2021	Crystal structure of the human PRPK-TPRKB complex.	6
29483219	2018	Targeting PRPK Function Blocks Colon Cancer Metastasis.	13
30053862	2018	A familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case report.	8
29483219	2018	Targeting PRPK Function Blocks Colon Cancer Metastasis.	13
30053862	2018	A familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case report.	8
28082445	2017	p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.	28
28082445	2017	p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.	28
24351856	2014	An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.	38
24351856	2014	An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.	38
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19
17712528	2007	Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB.	16

Citation

Dessen P

TP53RK (TP53 regulating kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43537/tp53rk-(tp53-regulating-kinase)