TRAF3IP1 (TRAF3 interacting protein 1)

2006-10-01  

Identity

HGNC
TRAF3IP1
LOCATION
2q37.3
LOCUSID
26146
ALIAS
FAP116,IFT54,MIP-T3,MIPT3,SLSN9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26146
MIM: 607380
HGNC: 17861
Ensembl: ENSG00000204104

Variants:

dbSNP: 26146
ClinVar: 26146
TCGA: ENSG00000204104
COSMIC: TRAF3IP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204104ENST00000373327Q8TDR0
ENSG00000204104ENST00000391993Q8TDR0
ENSG00000204104ENST00000409739H7BZ10

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
264872682015Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.40
192512512009Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.27
220799892011MIP-T3 is a negative regulator of innate type I IFN response.21
203915332010Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.6
129359002003MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.5
215109432011The C-terminus of MIP-T3 protein is required for ubiquitin-proteasome-mediated degradation in human cells.1

Citation

Dessen P

TRAF3IP1 (TRAF3 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43538/traf3ip1-(traf3-interacting-protein-1)