TRIP10 (thyroid hormone receptor interactor 10)

2006-10-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
CIP4,HSTP,STOT,STP,TRIP-10
FUSION GENES

Other Information

Locus ID:

NCBI: 9322
MIM: 604504
HGNC: 12304
Ensembl: ENSG00000125733

Variants:

dbSNP: 9322
ClinVar: 9322
TCGA: ENSG00000125733
COSMIC: TRIP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125733ENST00000313244Q15642
ENSG00000125733ENST00000313285Q15642
ENSG00000125733ENST00000596673M0R070
ENSG00000125733ENST00000596758W4VSQ9
ENSG00000125733ENST00000600428M0R0F9
ENSG00000125733ENST00000600677M0R2H7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177855062007Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.54
166306112006The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.40
209403942010Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.39
196323212009F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.25
126047782003Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.23
252032082014The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.21
300616812018FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.13
196314502010CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.11
212998692011Functional characterization of Trip10 in cancer cell growth and survival.11
258238232015CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.11

Citation

Dessen P

TRIP10 (thyroid hormone receptor interactor 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43543/trip10-(thyroid-hormone-receptor-interactor-10)