ULK1 (unc-51 like autophagy activating kinase 1)

2006-10-01  

Identity

HGNC
ULK1
LOCATION
12q24.33
LOCUSID
8408
ALIAS
ATG1,ATG1A,UNC51,Unc51.1,hATG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8408
MIM: 603168
HGNC: 12558
Ensembl: ENSG00000177169

Variants:

dbSNP: 8408
ClinVar: 8408
TCGA: ENSG00000177169
COSMIC: ULK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177169ENST00000321867O75385

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

References

Pubmed IDYearTitleCitations
377313352024AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.1
380398412024Role of CircCHD2 in the pathogenesis of gestational diabetes mellitus by regulating autophagy via miR-33b-3p/ULK1 axis.1
381356962024SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.1
382868022024Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.2
383246362024DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.0
384598842024RNF135 promotes cell proliferation and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.0
385174472024Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.0
386175332024IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.0
377313352024AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.1
380398412024Role of CircCHD2 in the pathogenesis of gestational diabetes mellitus by regulating autophagy via miR-33b-3p/ULK1 axis.1
381356962024SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.1
382868022024Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.2
383246362024DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.0
384598842024RNF135 promotes cell proliferation and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.0
385174472024Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.0

Citation

Dessen P

ULK1 (unc-51 like autophagy activating kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43551/ulk1-(unc-51-like-autophagy-activating-kinase-1)