ULK3 (unc-51 like kinase 3)

2006-10-01 Affiliation

Identity

HGNC

ULK3

LOCATION

15q24.1

LOCUSID

25989

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25989
MIM: 613472
HGNC: 19703
Ensembl: ENSG00000140474

Variants:

dbSNP: 25989
ClinVar: 25989
TCGA: ENSG00000140474
COSMIC: ULK3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140474	ENST00000440863	Q6PHR2
ENSG00000140474	ENST00000562161	H3BS27
ENSG00000140474	ENST00000563301	H3BT78
ENSG00000140474	ENST00000565373	H3BV76
ENSG00000140474	ENST00000565790	H3BTS3
ENSG00000140474	ENST00000566631	H3BPN6
ENSG00000140474	ENST00000568210	H3BMW8
ENSG00000140474	ENST00000568273	H3BMW8
ENSG00000140474	ENST00000568667	Q6PHR2
ENSG00000140474	ENST00000568679	H3BP85
ENSG00000140474	ENST00000569437	Q6PHR2
ENSG00000140474	ENST00000631115	H3BP85
ENSG00000140474	ENST00000647587	H3BP85

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'on' state	REACTOME	R-HSA-5632684

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10804	imatinib	Chemical	ClinicalAnnotation	associated		PD	15073101
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	ClinicalAnnotation	associated		PD	15073101

References

Pubmed ID	Year	Title	Citations
12471243	2002	The protein kinase complement of the human genome.	2088
19430479	2009	Genome-wide association study of blood pressure and hypertension.	542
20479155	2010	Blood pressure and hypertension are associated with 7 loci in the Japanese population.	63
19878745	2010	Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway.	34
21045733	2011	Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.	31
26011858	2015	ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.	25
20643644	2010	Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.	15
19141860	2009	Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia.	12
28877478	2017	The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI.	8
20959405	2010	The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.	7

Citation

Dessen P

ULK3 (unc-51 like kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43553/ulk3-(unc-51-like-kinase-3)