UMPS (uridine monophosphate synthetase)

2006-10-01  

Identity

HGNC
UMPS
LOCATION
3q21.2
LOCUSID
7372
ALIAS
OPRT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7372
MIM: 613891
HGNC: 12563
Ensembl: ENSG00000114491

Variants:

dbSNP: 7372
ClinVar: 7372
TCGA: ENSG00000114491
COSMIC: UMPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114491ENST00000232607P11172
ENSG00000114491ENST00000232607A8K5J1
ENSG00000114491ENST00000460034F2Z303
ENSG00000114491ENST00000462091F2Z3P2
ENSG00000114491ENST00000467167F2Z303
ENSG00000114491ENST00000474588F8WDG4
ENSG00000114491ENST00000479719E9PFD2
ENSG00000114491ENST00000497791F2Z3P2
ENSG00000114491ENST00000628619F2Z303

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMPKEGGM00051
Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMPKEGGhsa_M00051
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine biosynthesisREACTOMER-HSA-500753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPKPD16818689, 20647221
PA443448AstheniaDiseaseClinicalAnnotationassociatedPD28347776
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPKPD16818689, 20647221
PA445048NauseaDiseaseClinicalAnnotationassociatedPD28347776
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD28347776
PA446051VomitingDiseaseClinicalAnnotationassociatedPD28347776
PA448771capecitabineChemicalClinicalAnnotationassociatedPKPD16818689, 20647221, 28347776
PA450198leucovorinChemicalClinicalAnnotationassociatedPKPD16818689, 20647221
PA452620tegafurChemicalClinicalAnnotationassociatedPKPD16818689, 20647221

References

Pubmed IDYearTitleCitations
367089212023Human uridine 5'-monophosphate synthase stores metabolic potential in inactive biomolecular condensates.0
367089212023Human uridine 5'-monophosphate synthase stores metabolic potential in inactive biomolecular condensates.0
323821502020LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression.19
323821502020LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression.19
282050482017Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.5
283473332017A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.4
282050482017Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.5
283473332017A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.4
222493542013Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.18
241584422013Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.9
222493542013Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.18
241584422013Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.9
226416632012Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.4
229316172012[Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy].1
226416632012Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.4

Citation

Dessen P

UMPS (uridine monophosphate synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43555/umps-(uridine-monophosphate-synthetase)