Identity
HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
ATPBD1A,MBDIN,NTPBP,RPAP4,XAB1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11321
MIM: 611479
HGNC: 17030
Ensembl: ENSG00000198522
Variants:
dbSNP: 11321
ClinVar: 11321
TCGA: ENSG00000198522
COSMIC: GPN1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28940195 | 2017 | The Gpn3 Q279* cancer-associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting. | 2 |
| 29029378 | 2017 | Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner. | 0 |
| 28940195 | 2017 | The Gpn3 Q279* cancer-associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting. | 2 |
| 29029378 | 2017 | Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner. | 0 |
| 27749845 | 2016 | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. | 109 |
| 27749845 | 2016 | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. | 109 |
| 25241168 | 2014 | Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells. | 2 |
| 25241168 | 2014 | Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells. | 2 |
| 22796641 | 2012 | A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export. | 9 |
| 22796641 | 2012 | A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export. | 9 |
| 21768307 | 2011 | Human GTPases associate with RNA polymerase II to mediate its nuclear import. | 26 |
| 21768307 | 2011 | Human GTPases associate with RNA polymerase II to mediate its nuclear import. | 26 |
| 20855544 | 2010 | The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. | 50 |
| 20855544 | 2010 | The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. | 50 |
| 12588985 | 2003 | MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. | 20 |
Citation
Dessen P
GPN1 (GPN-loop GTPase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43557/gpn1-(gpn-loop-gtpase-1)
