GPN1 (GPN-loop GTPase 1)

2006-10-01  

Identity

HGNC
GPN1
LOCATION
2p23.3
LOCUSID
11321
ALIAS
ATPBD1A,MBDIN,NTPBP,RPAP4,XAB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11321
MIM: 611479
HGNC: 17030
Ensembl: ENSG00000198522

Variants:

dbSNP: 11321
ClinVar: 11321
TCGA: ENSG00000198522
COSMIC: GPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198522ENST00000264718Q9HCN4
ENSG00000198522ENST00000407583Q9HCN4
ENSG00000198522ENST00000424214Q9HCN4
ENSG00000198522ENST00000436280F8WD09
ENSG00000198522ENST00000458167Q9HCN4
ENSG00000198522ENST00000503738Q9HCN4
ENSG00000198522ENST00000515877Q9HCN4
ENSG00000198522ENST00000610189Q9HCN4
ENSG00000198522ENST00000610189Q53RZ9
ENSG00000198522ENST00000616939Q9HCN4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208555442010The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.37
277498452016Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.36
217683072011Human GTPases associate with RNA polymerase II to mediate its nuclear import.22
125889852003MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.17
227966412012A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export.7
252411682014Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells.2
289401952017The Gpn3 Q279* cancer-associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting.0
290293782017Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner.0

Citation

Dessen P

GPN1 (GPN-loop GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43557/gpn1-(gpn-loop-gtpase-1)