GRM5 (glutamate metabotropic receptor 5)

2007-02-01 Affiliation

Identity

HGNC

GRM5

LOCATION

11q14.2

LOCUSID

2915

ALIAS

GPRC1E,MGLUR5,PPP1R86,mGlu5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2915
MIM: 604102
HGNC: 4597
Ensembl: ENSG00000168959

Variants:

dbSNP: 2915
ClinVar: 2915
TCGA: ENSG00000168959
COSMIC: GRM5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168959	ENST00000305432	P41594
ENSG00000168959	ENST00000305447	P41594
ENSG00000168959	ENST00000393294	A8MT20
ENSG00000168959	ENST00000449371	H7C223
ENSG00000168959	ENST00000455756	P41594

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Gap junction	KEGG	ko04540
Long-term potentiation	KEGG	ko04720
Huntington's disease	KEGG	ko05016
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Gap junction	KEGG	hsa04540
Long-term potentiation	KEGG	hsa04720
Huntington's disease	KEGG	hsa05016
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Neuronal System	REACTOME	R-HSA-112316
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Protein-protein interactions at synapses	REACTOME	R-HSA-6794362
Interactions of neurexins and neuroligins at synapses	REACTOME	R-HSA-6794361

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12786977	2003	Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.	74
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18606955	2008	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.	55
21901840	2011	Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism.	48
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
12736269	2003	Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons.	41
22340009	2013	Role of mGluR5 neurotransmission in reinstated cocaine-seeking.	41
26667279	2016	Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.	37
18182392	2008	Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors.	35

Citation

Dessen P

GRM5 (glutamate metabotropic receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43586/grm5-(glutamate-metabotropic-receptor-5)