Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6531
MIM: 126455
HGNC: 11049
Ensembl: ENSG00000142319
Variants:
dbSNP: 6531
ClinVar: 6531
TCGA: ENSG00000142319
COSMIC: SLC6A3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000142319 | ENST00000270349 | Q01959 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | VariantAnnotation | ambiguous | PD | ||
| PA443842 | Death | Disease | VariantAnnotation | associated | PD | ||
| PA445254 | Parkinson Disease | Disease | ClinicalAnnotation | associated | PD | 25805645 | |
| PA446878 | Cocaine-Related Disorders | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 20580759 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 28182634 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 20580759 | |
| PA449072 | cocaine | Chemical | VariantAnnotation | associated | PD | ||
| PA449376 | disulfiram | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA450213 | levodopa | Chemical | ClinicalAnnotation | associated | PD | 25805645 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37578679 | 2024 | Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children. | 1 |
| 37578679 | 2024 | Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children. | 1 |
| 36754567 | 2023 | A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3). | 1 |
| 36912083 | 2023 | Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [(11)C]PE2I, [(18)F]FE-PE2I and [(11)C]raclopride PET in healthy individuals. | 0 |
| 37410882 | 2023 | Structure-Based Discovery of a Novel Allosteric Inhibitor against Human Dopamine Transporter. | 2 |
| 37459244 | 2023 | Effects of STN-DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease. | 1 |
| 37628576 | 2023 | LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma. | 1 |
| 37726104 | 2023 | Association between longitudinal changes in striatal dopamine transporter uptake and clinical features of dementia with Lewy bodies. | 1 |
| 36754567 | 2023 | A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3). | 1 |
| 36912083 | 2023 | Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [(11)C]PE2I, [(18)F]FE-PE2I and [(11)C]raclopride PET in healthy individuals. | 0 |
| 37410882 | 2023 | Structure-Based Discovery of a Novel Allosteric Inhibitor against Human Dopamine Transporter. | 2 |
| 37459244 | 2023 | Effects of STN-DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease. | 1 |
| 37628576 | 2023 | LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma. | 1 |
| 37726104 | 2023 | Association between longitudinal changes in striatal dopamine transporter uptake and clinical features of dementia with Lewy bodies. | 1 |
| 34845656 | 2022 | Functional SLC6A3 polymorphisms differentially affect autism spectrum disorder severity: a study on Indian subjects. | 3 |
Citation
Dessen P
SLC6A3 (solute carrier family 6 member 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43591/slc6a3-(solute-carrier-family-6-member-3)
