HNRNPF (heterogeneous nuclear ribonucleoprotein F)

2007-02-01 Affiliation

Identity

HGNC

HNRNPF

LOCATION

10q11.21

LOCUSID

3185

ALIAS

HNRPF,OK/SW-cl.23,mcs94-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3185
MIM: 601037
HGNC: 5039
Ensembl: ENSG00000169813

Variants:

dbSNP: 3185
ClinVar: 3185
TCGA: ENSG00000169813
COSMIC: HNRNPF

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169813	ENST00000337970	P52597
ENSG00000169813	ENST00000337970	A0A024R7T3
ENSG00000169813	ENST00000356053	P52597
ENSG00000169813	ENST00000356053	A0A024R7T3
ENSG00000169813	ENST00000357065	P52597
ENSG00000169813	ENST00000357065	A0A024R7T3
ENSG00000169813	ENST00000443950	P52597
ENSG00000169813	ENST00000443950	A0A024R7T3
ENSG00000169813	ENST00000477108	A0A1B0GW42
ENSG00000169813	ENST00000544000	P52597
ENSG00000169813	ENST00000544000	A0A024R7T3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
FGFR2 alternative splicing	REACTOME	R-HSA-6803529

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11158309	2001	hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells.	69
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
20526337	2010	Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.	55
16885237	2006	NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.	43
16424007	2006	Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.	27
29269483	2017	RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF.	25
22132154	2011	hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.	24
20308064	2010	Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.	22
19244236	2009	Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.	21
20308327	2010	A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.	17

Citation

Dessen P

HNRNPF (heterogeneous nuclear ribonucleoprotein F)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43592/hnrnpf-(heterogeneous-nuclear-ribonucleoprotein-f)