APOH (apolipoprotein H)

2007-02-01  

Identity

HGNC
LOCATION
17q24.2
LOCUSID
ALIAS
B2G1,B2GP1,BG
FUSION GENES

Other Information

Locus ID:

NCBI: 350
MIM: 138700
HGNC: 616
Ensembl: ENSG00000091583

Variants:

dbSNP: 350
ClinVar: 350
TCGA: ENSG00000091583
COSMIC: APOH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091583ENST00000205948P02749
ENSG00000091583ENST00000205948A0A384NKM6
ENSG00000091583ENST00000577982J3QRN2
ENSG00000091583ENST00000581797J3QLI0
ENSG00000091583ENST00000585162J3KS17

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
159562882005Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor.65
196949462009The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study.50
215353912011β(2) -Glycoprotein I: evolution, structure and function.42
128078922003Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.33
170967062007Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'.30
216184592011Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I.30
125628692003Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
155072632004Beta 2 glycoprotein I--function in health and disease.26

Citation

Dessen P

APOH (apolipoprotein H)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43597/apoh-(apolipoprotein-h)