ADAM8 (ADAM metallopeptidase domain 8)

2007-02-01  

Identity

HGNC
ADAM8
LOCATION
10q26.3
LOCUSID
101
ALIAS
CD156,CD156a,MS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 101
MIM: 602267
HGNC: 215
Ensembl: ENSG00000151651

Variants:

dbSNP: 101
ClinVar: 101
TCGA: ENSG00000151651
COSMIC: ADAM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151651ENST00000415217P78325
ENSG00000151651ENST00000445355P78325
ENSG00000151651ENST00000485491P78325
ENSG00000151651ENST00000486609H0YMT6
ENSG00000151651ENST00000560135H0YKZ1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
173390472007Increased expression of ADAM33 and ADAM8 with disease progression in asthma.53
175486432007Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.33
242472442014A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
156236142004ADAM8 as a novel serological and histochemical marker for lung cancer.25
243756282014ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.25
179798912007ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.19
197146412009ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).16
236701892013Adam8 limits the development of allergic airway inflammation in mice.15

Citation

Dessen P

ADAM8 (ADAM metallopeptidase domain 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43603/adam8-(adam-metallopeptidase-domain-8)