IL7 (interleukin 7)

2007-02-01 Affiliation

Identity

HGNC

IL7

LOCATION

8q21.13

LOCUSID

3574

ALIAS

IL-7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3574
MIM: 146660
HGNC: 6023
Ensembl: ENSG00000104432

Variants:

dbSNP: 3574
ClinVar: 3574
TCGA: ENSG00000104432
COSMIC: IL7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104432	ENST00000263851	P13232
ENSG00000104432	ENST00000379113	Q5FBX5
ENSG00000104432	ENST00000518982	Q5FBY3
ENSG00000104432	ENST00000520215	Q5FBY6
ENSG00000104432	ENST00000520269	P13232
ENSG00000104432	ENST00000520317	Q5FBY6
ENSG00000104432	ENST00000541183	A0A0A0MTG5
ENSG00000104432	ENST00000639719	Q5FBY3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Hematopoietic cell lineage	KEGG	ko04640
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Hematopoietic cell lineage	KEGG	hsa04640
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-7 signaling	REACTOME	R-HSA-1266695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23160470	2013	IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.	161
15353558	2004	Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells.	102
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
17110377	2007	Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells.	89
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
23053510	2012	IL-7 restores lymphocyte functions in septic patients.	72
20546594	2010	An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.	71
20190192	2010	IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.	68
22955921	2012	IL-7-producing stromal cells are critical for lymph node remodeling.	65

Citation

Dessen P

IL7 (interleukin 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43614/il7-(interleukin-7)