Identity
HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
LAPTM4beta,LC27
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55353
MIM: 613296
HGNC: 13646
Ensembl: ENSG00000104341
Variants:
dbSNP: 55353
ClinVar: 55353
TCGA: ENSG00000104341
COSMIC: LAPTM4B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000104341 | ENST00000445593 | Q86VI4 |
| ENSG00000104341 | ENST00000517924 | H0YBN1 |
| ENSG00000104341 | ENST00000521545 | Q86VI4 |
| ENSG00000104341 | ENST00000619747 | Q86VI4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Lysosome | KEGG | ko04142 |
| Lysosome | KEGG | hsa04142 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38388484 | 2024 | LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy. | 0 |
| 38388484 | 2024 | LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy. | 0 |
| 36758682 | 2023 | LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis. | 1 |
| 36758682 | 2023 | LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis. | 1 |
| 35863479 | 2022 | Screening of four key genes in esophageal carcinoma based on TCGA and GEO data and verification of anti-proliferative effect of LAPTM4B knockdown in esophageal carcinoma cells invitro. | 0 |
| 35863479 | 2022 | Screening of four key genes in esophageal carcinoma based on TCGA and GEO data and verification of anti-proliferative effect of LAPTM4B knockdown in esophageal carcinoma cells invitro. | 0 |
| 33181324 | 2021 | LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles. | 7 |
| 34393233 | 2021 | [Serum LAPTM4B-35 protein as a novel diagnostic marker for hepatocellular carcinoma]. | 2 |
| 33181324 | 2021 | LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles. | 7 |
| 34393233 | 2021 | [Serum LAPTM4B-35 protein as a novel diagnostic marker for hepatocellular carcinoma]. | 2 |
| 32679228 | 2020 | Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover. | 4 |
| 33090522 | 2020 | Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release. | 13 |
| 32679228 | 2020 | Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover. | 4 |
| 33090522 | 2020 | Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release. | 13 |
| 30778748 | 2019 | Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma. | 3 |
Citation
Dessen P
LAPTM4B (lysosomal protein transmembrane 4 beta)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43622/laptm4b-(lysosomal-protein-transmembrane-4-beta)
