MAT2A (methionine adenosyltransferase 2A)

2007-02-01  

Identity

HGNC
MAT2A
LOCATION
2p11.2
LOCUSID
4144
ALIAS
MATA2,MATII,SAMS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4144
MIM: 601468
HGNC: 6904
Ensembl: ENSG00000168906

Variants:

dbSNP: 4144
ClinVar: 4144
TCGA: ENSG00000168906
COSMIC: MAT2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168906ENST00000306434P31153
ENSG00000168906ENST00000306434A0A140VJP5
ENSG00000168906ENST00000409017P31153

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine degradationKEGGhsa_M00035
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
Methionine degradationKEGGM00035
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375677862023Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.1
375677862023Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.1
351827292022Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.14
354827242022Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.2
351827292022Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.14
354827242022Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.2
324926982021Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.1
334501962021MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.64
335938292021Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer.15
339493102021SAM homeostasis is regulated by CFI(m)-mediated splicing of MAT2A.18
340653902021MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients.12
342582962021Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development.4
343264692021Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.14
346102462021MALAT1 Inhibits Proliferation of HPV16-Positive Cervical Cancer by Sponging miR-485-5p to Promote Expression of MAT2A.10
346164062021MAT2A-Mediated S-Adenosylmethionine Level in CD4(+) T Cells Regulates HIV-1 Latent Infection.3

Citation

Dessen P

MAT2A (methionine adenosyltransferase 2A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43637/mat2a-(methionine-adenosyltransferase-2a)