LIPC (lipase C, hepatic type)

2012-05-01  

Identity

HGNC
LIPC
LOCATION
15q21.3
LOCUSID
3990
ALIAS
HDLCQ12,HL,HTGL,LIPH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3990
MIM: 151670
HGNC: 6619
Ensembl: ENSG00000166035

Variants:

dbSNP: 3990
ClinVar: 3990
TCGA: ENSG00000166035
COSMIC: LIPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166035ENST00000299022P11150
ENSG00000166035ENST00000356113P11150
ENSG00000166035ENST00000414170E7EUJ1
ENSG00000166035ENST00000433326E7EUK6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Acylglycerol degradationKEGGhsa_M00098
Acylglycerol degradationKEGGM00098
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Digestion of dietary lipidREACTOMER-HSA-192456
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449688fluvastatinChemicalClinicalAnnotationassociatedPD16103896
PA451089pravastatinChemicalClinicalAnnotationassociatedPD16103896, 16115483
PA451363simvastatinChemicalClinicalAnnotationassociatedPD16103896

References

Pubmed IDYearTitleCitations
374604252023[Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype].0
374604252023[Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype].0
358996252022Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia.3
362741322022Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.2
358996252022Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia.3
362741322022Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.2
326178582021The -514C>T polymorphism in the LIPC gene modifies type 2 diabetes risk through modulation of HDL-cholesterol levels in Mexicans.5
334994102021Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies.4
336737892021Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study.0
326178582021The -514C>T polymorphism in the LIPC gene modifies type 2 diabetes risk through modulation of HDL-cholesterol levels in Mexicans.5
334994102021Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies.4
336737892021Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study.0
319478862020The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations.10
321966712020Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil.1
326031852020Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase).2

Citation

Dessen P

LIPC (lipase C, hepatic type)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/43641/lipc-(lipase-c-hepatic-type)