Identity
HGNC
LOCATION
8q24.13
LOCUSID
ALIAS
C8orf36,MMS21,NSE2,ZMIZ7
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 286053
MIM: 617246
HGNC: 26513
Ensembl: ENSG00000156831
Variants:
dbSNP: 286053
ClinVar: 286053
TCGA: ENSG00000156831
COSMIC: NSMCE2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36224576 | 2022 | NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer. | 5 |
| 36224576 | 2022 | NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer. | 5 |
| 30590722 | 2019 | A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest. | 17 |
| 30735491 | 2019 | Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage. | 16 |
| 30590722 | 2019 | A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest. | 17 |
| 30735491 | 2019 | Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage. | 16 |
| 27792189 | 2016 | Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. | 18 |
| 27792189 | 2016 | Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. | 18 |
| 25105364 | 2014 | Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. | 54 |
| 25245984 | 2014 | 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. | 23 |
| 25105364 | 2014 | Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. | 54 |
| 25245984 | 2014 | 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. | 23 |
| 22751501 | 2012 | Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. | 51 |
| 22751501 | 2012 | Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. | 51 |
| 21550342 | 2011 | The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability. | 28 |
Citation
Dessen P
NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43647/nsmce2-(nse2-(mms21)-homolog-smc5-smc6-complex-sumo-ligase)
