CD276 (CD276 molecule)

2007-02-01  

Identity

HGNC
CD276
LOCATION
15q24.1
LOCUSID
80381
ALIAS
4Ig-B7-H3,B7-H3,B7H3,B7RP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80381
MIM: 605715
HGNC: 19137
Ensembl: ENSG00000103855

Variants:

dbSNP: 80381
ClinVar: 80381
TCGA: ENSG00000103855
COSMIC: CD276

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103855ENST00000318424Q5ZPR3
ENSG00000103855ENST00000318443Q5ZPR3
ENSG00000103855ENST00000537340A0A0C4DGH0
ENSG00000103855ENST00000558689H0YN85
ENSG00000103855ENST00000559073H0YN29
ENSG00000103855ENST00000560786H0YK40
ENSG00000103855ENST00000560928H0YLT3
ENSG00000103855ENST00000560995H0YLT8
ENSG00000103855ENST00000561176H0YL10
ENSG00000103855ENST00000561213Q5ZPR3
ENSG00000103855ENST00000561260H0YK59
ENSG00000103855ENST00000561416H0YKQ9
ENSG00000103855ENST00000563584H3BM68
ENSG00000103855ENST00000564751Q5ZPR3
ENSG00000103855ENST00000567189H0YLT8
ENSG00000103855ENST00000567582H0YLT3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374056862024B7-H3 Regulates Glucose Metabolism in Neuroblastom via Stat3/c-Met Pathway.1
377684392024B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention.0
377987542024Expression of B7-H3 and TIM-3 in gastric-type endocervical adenocarcinoma: prevalence, association with PD-L1 expression, and prognostic significance.0
380361072024B7-H3 regulates anti-tumor immunity and promotes tumor development in colorectal cancer.2
381345172024B7-H3 promotes angiogenesis in rheumatoid arthritis.0
381826522024Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling.2
383649612024Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.0
385209532024B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma.0
386000022024Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma.0
387244652024CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.0
388587152024B7-H3 and ICAM-1 are potentially therapeutic targets for thyroid carcinoma.0
374056862024B7-H3 Regulates Glucose Metabolism in Neuroblastom via Stat3/c-Met Pathway.1
377684392024B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention.0
377987542024Expression of B7-H3 and TIM-3 in gastric-type endocervical adenocarcinoma: prevalence, association with PD-L1 expression, and prognostic significance.0
380361072024B7-H3 regulates anti-tumor immunity and promotes tumor development in colorectal cancer.2

Citation

Dessen P

CD276 (CD276 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43652/cd276-(cd276-molecule)