NFAT5 (nuclear factor of activated T cells 5)

2007-02-01  

Identity

HGNC
NFAT5
LOCATION
16q22.1
LOCUSID
10725
ALIAS
NF-AT5,NFATL1,NFATZ,OREBP,TONEBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10725
MIM: 604708
HGNC: 7774
Ensembl: ENSG00000102908

Variants:

dbSNP: 10725
ClinVar: 10725
TCGA: ENSG00000102908
COSMIC: NFAT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102908ENST00000349945O94916
ENSG00000102908ENST00000354436O94916
ENSG00000102908ENST00000393742A0A499FIS8
ENSG00000102908ENST00000426654O94916
ENSG00000102908ENST00000563474J3KRL6
ENSG00000102908ENST00000565301J3QKS5
ENSG00000102908ENST00000566899A0A499FJX5
ENSG00000102908ENST00000567239O94916
ENSG00000102908ENST00000567990H3BP21
ENSG00000102908ENST00000627621A0A494C020
ENSG00000102908ENST00000650987A0A494C020

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseLiterature, MultilinkAnnotationassociated24560520

References

Pubmed IDYearTitleCitations
383387162024TonEBP: A Key Transcription Factor in Microglia Following Intracerebral Hemorrhage Induced-Neuroinflammation.0
384388722024TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells.0
386124782024Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells.0
387243212024Differentiation and immunosuppressive function of CD19(+)CD24(hi)CD27(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway.0
383387162024TonEBP: A Key Transcription Factor in Microglia Following Intracerebral Hemorrhage Induced-Neuroinflammation.0
384388722024TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells.0
386124782024Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells.0
387243212024Differentiation and immunosuppressive function of CD19(+)CD24(hi)CD27(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway.0
366521822023SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway via NFAT5.1
381886782023TonEBP expression is essential in the IL-1β-induced migration and invasion of human A549 lung cancer cells.0
366521822023SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway via NFAT5.1
381886782023TonEBP expression is essential in the IL-1β-induced migration and invasion of human A549 lung cancer cells.0
354179132022Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma.0
354179132022Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma.0
328288832021Up-Regulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy.2

Citation

Dessen P

NFAT5 (nuclear factor of activated T cells 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43657/nfat5-(nuclear-factor-of-activated-t-cells-5)