MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A)
2007-02-01 AffiliationIdentity
HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
GNT-IV,GNT-IVA,GnT-4a
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11320
MIM: 604623
HGNC: 7047
Ensembl: ENSG00000071073
Variants:
dbSNP: 11320
ClinVar: 11320
TCGA: ENSG00000071073
COSMIC: MGAT4A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10040 | cetuximab | Chemical | ClinicalAnnotation | associated | PD | 26222057 | |
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 26222057 | |
| PA131285527 | oxaliplatin | Chemical | ClinicalAnnotation | associated | PD | 26222057 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 26222057 | |
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | 26222057 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37295747 | 2023 | N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin β1 with vimentin and promotes hepatocellular carcinoma cell motility. | 0 |
| 37295747 | 2023 | N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin β1 with vimentin and promotes hepatocellular carcinoma cell motility. | 0 |
| 28534963 | 2017 | N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. | 5 |
| 28534963 | 2017 | N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. | 5 |
| 26589799 | 2016 | MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression. | 18 |
| 26589799 | 2016 | MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression. | 18 |
| 23169300 | 2012 | High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. | 14 |
| 23169300 | 2012 | High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. | 14 |
| 19751437 | 2009 | Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. | 3 |
| 19751437 | 2009 | Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. | 3 |
| 17488527 | 2007 | N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. | 27 |
| 17953760 | 2007 | The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients. | 3 |
| 17488527 | 2007 | N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. | 27 |
| 17953760 | 2007 | The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients. | 3 |
| 16434023 | 2006 | Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. | 17 |
Citation
Dessen P
MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43659/mgat4a-(alpha-1-3-mannosyl-glycoprotein-4-beta-n-acetylglucosaminyltransferase-a)
