KIR2DL1 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1)

2007-02-01  

Identity

HGNC
KIR2DL1
LOCATION
19q13.42
LOCUSID
3802
ALIAS
CD158A,KIR-K64,KIR221,KIR2DL3,NKAT,NKAT-1,NKAT1,p58.1

Other Information

Locus ID:

NCBI: 3802
MIM: 604936
HGNC: 6329
Ensembl: ENSG00000125498

Variants:

dbSNP: 3802
ClinVar: 3802
TCGA: ENSG00000125498
COSMIC: KIR2DL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125498ENST00000291633P43626
ENSG00000125498ENST00000336077Q6H2H3

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
382405272024KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.0
382628742024Activating KIR/HLA-I combinations as a risk factor of adult B-ALL.0
382405272024KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.0
382628742024Activating KIR/HLA-I combinations as a risk factor of adult B-ALL.0
378010922023The KIR2DL1 intermediate upstream element participates in gene activation.0
378010922023The KIR2DL1 intermediate upstream element participates in gene activation.0
367134002022Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.2
367134002022Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.2
339067892021Lack of association of KIR2DL1-R(245) and KIR2DL1-C(245) with HIV-1 control in black South Africans with HLA-C2.0
339067892021Lack of association of KIR2DL1-R(245) and KIR2DL1-C(245) with HIV-1 control in black South Africans with HLA-C2.0
329831082020Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.11
329831082020Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.11
306988602019Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC.9
315198642019KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals.17
306988602019Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC.9

Citation

Dessen P

KIR2DL1 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43665/kir2dl1-(killer-cell-immunoglobulin-like-receptor-two-ig-domains-and-long-cytoplasmic-tail-1)